Examples
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The following images depict molecular
sculptures of two objects, a dimer of amino acids (Cys-Cys) and the active site
of the enzyme, mouse MMP-13. Both structures were determined in this laboratory.
The Cys-Cys dimer is the only dimer linkage among amino acids in
a protein, its strength coming from the S-S covalent bond.
MMP-13 was first found in human breast cancer tissue; the object
of the research is to explore the nature of inhibitor binding as a guide for the
creation of potent and effective anti-cancer drugs.
These sculptures are carved from wood (oak, maple) by a CNC
milling machine and are approximately 17cm (7 inches) high (or long). The images
represent various steps in the learning process to produce precisely scaled 3-D
molecular models.
42Cys-58Cys disulfide linkage |
42Cys-58Cys disulfide linkage |
42Cys-58Cys disulfide linkage |
42Cys-58Cys disulfide linkage |
42Cys-58Cys disulfide linkage |
N3-Zn complex/MMP-13 |
3His-Zn complex/MMP-13 |
42Cys-58Cys disulfide linkage |
42Cys-58Cys disulfide linkage |
42Cys-58Cys disulfide linkage |
42Cys-58Cys disulfide linkage |
42Cys-58Cys disulfide linkage |
| E. Meyer Biographics Laboratory Texas A&M University E-Meyer@tamu.edu Copyright January, 2000 |